786 results
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
Left Shift (↓ O2 unloading ... Right Shift (↑O2 unloading ... Dissociation #Curve #pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
Shift - decreased unloading ... Shift - increased unloading ... Dissociation #Curve #Pathophysiology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
facilitates oxygen unloading ... Diagnosis #Algorithm #Pathophysiology
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... #orthopedics #pathophysiology
VA ECMO Unloading - LV Venting
Different LV Venting Strategies work through these basic mechanisms: ↓ Preload,
VA ECMO Unloading ... karanpdesai #VAECMO #Unloading
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology
Disc Herniations - Pathogenesis and Complications
• 90% of Lumbar disc herniations happen at L4/5 and L5/S1
•
-> Mechanical loading ... complications #msk #pathophysiology
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework

Hematologic & Vascular:
 • Multiple myeloma & Acute leukemia (plasma cells
bleeding (↑ nitrogen loading ... Differential #Diagnosis #Pathophysiology
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
bone -> Pain with loading ... Osteoarthritis #OA #pathophysiology
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Rivaroxaban #Edoxaban #Loading