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diagnosis differential causes hypokalemia management potassium treatment rhabdomyolysis hematology hyponatremia hypotonic intercellularshift k leukostasis lysis physiologic sodium summary tumor tumorlysis
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... (TLS) Tumor Cell ... Precipitation => • Urate ... Hypocalcemia • Hyperkalemia ... #TLS #Pathophysiology
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... , Gitelman syndrom ... @priti899 #Hypokalemia ... #nephrology
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... Diagnosis Algorithm ... , Gitelman's syndrome ... #Hypokalemia # ... #nephrology #causes
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Algorithm Before ... consumption • Low ... , Gitelman syndrome ... differential #potassium #nephrology ... #low
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
Algorithm for patients ... with hypokalemia ... , Gitelman syndrome ... #hypokalemia ... #diagnosis #nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... fever - ACS, AKI ... , Elevated Cr, Low ... hydration - Hyperkalemia ... #TLS #diagnosis
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... : Hypovolemia, Hypervolemia ... Cirrhosis, Nephrotic syndrome ... differential #diagnosis #table ... #sodium #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal or low ... #nephrology #management ... #pathophysiology ... #Hypokalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
HIV, Influenza, TSS ... declines > ALT) • AKI ... + myoglobin AKI ... per day until stable ... causes #treatment #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
HIV, Influenza, TSS ... Dermatomyositis) AKI ... - Pathophysiology ... per day until stable ... Dialysis for severe hyperkalemia
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