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diagnosis differential causes hematology hyponatremia hypotonic leukostasis lysis management physiologic sodium table tumor tumorlysis uricacid
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... (TLS) Tumor Cell ... Precipitation => • Urate ... Hypocalcemia • Hyperkalemia ... #TLS #Pathophysiology
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm Reduced flow through distal nephron - TTKG
Causes of Hyperkalemia ... Differential Diagnosis Algorithm ... renal failure • AKI ... #IntercellularShift ... #Nephrology #Differential
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm Transcellular Shift - Appropriate renal excretion (GFR,
, TTKG, distal flow ... Osmoles, Increased Urate ... Tumor Lysis Syndrome ... #IntercellularShift ... #Nephrology #Differential
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... fever - ACS, AKI ... , Elevated Cr, Low ... hydration - Hyperkalemia ... #TLS #diagnosis
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... can be high or low ... : Hypovolemia, Hypervolemia ... Cirrhosis, Nephrotic syndrome ... table #sodium #nephrology
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