10 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Renal Tubular Defects ... Proximal tubule Bartter ... #Fanconi #Bartter ... #Pathophysiology ... #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... acid transporter Bartter ... ascending limb Gitelman ... of epithelial sodium ... #Kidney #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Bartter syndrome ... • Pseudo Bartter-Gitelman ... #nephrology #management ... #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... (BBB), and infects ... volume • Patchy areas ... The clinical syndrome ... dementia #AIDS #Neurology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter ... syndrome, Gitelman ... syndrome, Hypomagnesemia ... #nephrology #differential
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
diuretic effect has ... tubule reabsorptive defect ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... Pathophysiology: ... • Associated with ... • Urine sodium ... #Nephrology #Diagnosis
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
men • Commonly associated ... Pathophysiology ... : • Associated ... diaphoresis, high HR ... others (botox, sodium
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
claudication, pulse deficits ... • ESR > 50mm/hr ... impairment, neurologic deficits ... white and gray matter ... VASCULITIS: ANCA Associated
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
Principles of HIV-Associated ... Periventricular regions; associated ... Symptoms: AMS, motor deficits ... periventricular areas ... • EBV analysis has