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diagnosis signs differential lupus neurology caudaequina cord disorders erythematosus hematology leukemia management manifestations mucocutaneous musculoskeletal myelitis oncology spinal spinalcord systemic
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Myopathy (Also caused ... #MSK #Musculoskeletal ... #Complications ... #pathophysiology ... #signs #symptoms
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... spine Signs / Symptoms ... / Complications ... #MSK #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
in sun exposed areas ... hair follicles -> causes ... Manifestations #pathophysiology ... diagnosis #signs #symptoms ... #complications
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Intracellular Urate ... Transformation: • Complication
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Non-compressive Spinal Cord Causes ... Behcet disease - SLE ... MCTD, Sjogren syndrome ... disorders #diagnosis #neurology ... differential #algorithm
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Bilateral signs and/or symptoms ... Evaluate for NMO, SLE ... Disorders: - SLE ... diagnosis #management #neurology
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