18 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... Extra-renal Losses: • Normal ... , Gitelman syndrom ... Differential #Diagnosis #Algorithm ... potassium #low #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... #nephrology #management ... #pathophysiology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Differential Diagnosis Algorithm ... Al, Normal R - ... , Gitelman's syndrome ... Differential #Diagnosis #Algorithm ... #nephrology #causes
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... the excretion of sodium ... #nephrology #differential
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Algorithm for patients ... Low-normal EABV ... , Gitelman syndrome ... #differential #algorithm ... #diagnosis #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... consumption • Low/Normal ... , Gitelman syndrome ... Hypokalemia #diagnosis #Algorithm ... differential #potassium #nephrology
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Repeat the sodium ... NORMAL PLASMA OSMOLALITY ... • nephrotic syndrome ... Diagnosis #Workup #Algorithm ... #Nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... electrolytes, urea ... investigations abnormal ... clinical context and signs ... Differential #Diagnosis #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... - Bartter - Gitelman ... SIGNS: • Muscle ... #Pathophysiology ... #Nephrology #Chloride