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diagnosis differential management causes treatment rhabdomyolysis hematology hyponatremia hypotonic intercellularshift k leukostasis physiologic potassium sodium summary tumor tumorlysis uricacid
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... Precipitation => • Urate ... Hypocalcemia • Hyperkalemia ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... fever - ACS, AKI ... Syndrome: • Pathophysiology ... hydration - Hyperkalemia ... #Syndrome #TLS
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Differential Diagnosis Algorithm ... Osmoles, Increased Urate ... Tumor Lysis Syndrome ... IntercellularShift #Nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
HIV, Influenza, TSS ... declines > ALT) • AKI ... + myoglobin AKI ... per day until stable ... causes #treatment #nephrology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... : Hypovolemia, Hypervolemia ... Cirrhosis, Nephrotic syndrome ... differential #diagnosis #table ... #sodium #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
HIV, Influenza, TSS ... Dermatomyositis) AKI ... - Pathophysiology ... per day until stable ... Dialysis for severe hyperkalemia
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis ... (TLS, rhabdo/crush ... , RTA Type IV, AI ... Elimination (see Table ... Treatment #potassium #nephrology
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