21 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Uric Acid (low ... excretion) • Phosphorus ... Precipitation => • Urate
Hypophosphatemia Diagnostic Algorithm
- GI Losses
- Redistribution
- 1° HPT
- 1° Renal PO4 wasting: Hereditary, TIO, Fanconi Syndrome,
, TIO, Fanconi Syndrome ... Hypophosphatemia #phosphorus ... #low #diagnosis ... #Algorithm #differential ... #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Differential Diagnosis Algorithm ... Urine Cl-: Vomiting ... (late) • High Urine ... Differential #Diagnosis #Algorithm ... #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Differential Diagnosis Algorithm ... Urine Cl-: Vomiting ... (late) • High Urine ... Differential #Diagnosis #Algorithm ... #Nephrology #Causes
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
ADH promotes Urea ... Osmolarity 2) Urine ... Uric Acid - Low ... #nephrology #sodium ... #low #uricacid
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Algorithm for patients ... Low-normal EABV ... , Low Plasma HCO3 ... #differential #algorithm ... #diagnosis #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
leukemia Measure Urine ... absorption (Antacids, Phosphorus ... • Normal or Low ... - Normal or Low ... Workup #phosphate #nephrology
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Hypothyroidism, Low ... Cirrhosis, Nephrotic syndrome ... #Hyponatremia #algorithm ... diagnosis #sodium #low ... #nephrology
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Differential Diagnosis Algorithm ... Appropriately Low ... Tumor Genesis Syndrome ... Differential #Diagnosis #Algorithm ... #nephrology #phosphorus
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... A urine K/Cr ratio ... • Diarrhea A urine ... differential #potassium #nephrology ... #low