12 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Renal Tubular Defects ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... #Pathophysiology ... #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... ascending limb Gitelman ... #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
- Gitelman ... syndrome - ... Genetic defects ... Hypomagnesemia #Differential ... Low #Magnesium #Table
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Kidney Injury - AKI ... electrolytes, urea ... Abdominal compartment syndrome ... • Cardio-renal syndrome ... #Diagnosis #nephrology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
) - Differential ... • Hepatorenal syndromes ... multiple myeloma) • Urate ... #KidneyInjury #Nephrology ... #Differential #
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
Renal Losses (AKI ... Cirrhosis, Nephrotic syndrome ... #Hyponatremia #differential ... #diagnosis #table ... #sodium #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Metabolic Alkalosis: Differential ... tubule reabsorptive defect ... furosemide-like lesion) • Gitelman ... Metabolic #Alkalosis #Differential ... Diagnosis #Causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... ratio 0.5%) Differential ... #nephrology #management ... #pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Rhabdomyolysis - Differential ... iniury, Compartment syndrome ... Dermatomyositis) AKI ... - Pathophysiology ... per day until stable
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... declines > ALT) • AKI ... + myoglobin AKI ... per day until stable ... causes #treatment #nephrology