11 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Renal Tubular Defects ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... #Pathophysiology ... #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Normal Acid-Base: Low ... Ureterosigmoidoscopy • HTN, Low ... , Gitelman syndrom ... Algorithm #causes #potassium ... #low #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypertensive: • High Al, Low ... acid, Liddle's Syndrome ... , Gitelman's syndrome ... Diagnosis #Algorithm #nephrology ... #causes #low #potassium
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the basis of the potassium-to-creatinine ... Low-normal EABV ... , Gitelman syndrome ... hypokalemia #urine #potassium ... algorithm #diagnosis #nephrology
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
- Gitelman ... syndrome - ... Genetic defects ... Differential #Diagnosis #Low ... #Magnesium #Table
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... consumption • Low ... , Gitelman syndrome ... #differential #potassium ... #nephrology #low
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... ascending limb Gitelman ... Epithelial #Inherited #Defects ... #Kidney #Nephrology ... #Differential #Table
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal or low ... Supplement: • Potassium ... #nephrology #management ... #pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
tubule reabsorptive defect ... furosemide-like lesion) • Gitelman ... syndrome (defective ... other • Severe potassium ... Diagnosis #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... of sodium and potassium ... urine #Algorithm #nephrology