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Diabetes Insipidus vs Syndrome of Inappropriate ADH (SIADH) - Comparison Table

Diabetes Insipidus - Inadequate ADH
SIADH -
Diabetes Insipidus vs Syndrome ... Inappropriate ADH ... (SIADH) - Comparison ... #Comparison #Table ... #Pathophysiology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
- Pathophysiology ... Hypovolaemia → ADH ... → Increased urine ... #diagnosis #nephrology ... #hyponatremia #comparison
Urine Specific Gravity - Interpretation
Specific Gravity = Density of urine / Density of water
SG close to
resistance to ADH ... Dehydration • SIADH ... (syndrome of inappropriate ... ADH) • CHF • ... #differential #nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Utilizing Uric Acid ADH ... promotes Urea/uric ... Osmolarity 2) Urine ... Low Uric Acid → SIADH ... Diagnosis #Algorithm #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
volume-based algorithm Urine ... restriction alone in SIADH ... Present (Uosm ≥100): SIADH ... Cirrhosis, Nephrotic syndrome ... table #sodium #nephrology
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... volume overload Urea ... Saline: • If Urine ... antagonists: • Blocks ADH ... #hyponatremia #nephrology
SIADH Treatment Options
1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
Urea powder • Induces ... 0.9% NS • If Urine ... vaptans) • Blocks ADH ... Hypotension, Increased urine ... #hyponatremia #nephrology
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
body water in comparison ... serum osmolality, urine ... concentration and urine ... Rise in blood urea ... EBV #potomania #SIADH
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... Monosodium urate ... • Metabolic syndrome ... predominance • Urate ... #Gout #Comparison
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
electrolytes, urea ... Abdominal compartment syndrome ... fragmentocytes, LDH ... • Cardio-renal syndrome ... Differential #Diagnosis #nephrology