17 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... Precipitation => • Urate ... Nephropathy (low urine ... #UricAcid
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
ADH promotes Urea ... Osmolarity 2) Urine ... Osmolarity 3) Urine ... #nephrology #sodium ... #low #uricacid
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... Low intake • Metabolic ... Renal Losses: • Metabolic ... #causes #potassium ... #low #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... treated with IV potassium ... A urine K/Cr ratio ... • Diarrhea A urine ... #nephrology #low
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Differential Diagnosis Algorithm ... (late) • High Urine ... #Primary #Metabolic ... #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Differential Diagnosis Algorithm ... hyperaldosteronism • Low Urine ... (late) • High Urine ... #Nephrology #Causes
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... of sodium and potassium ... #Algorithm #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Algorithm for patients ... the basis of the potassium-to-creatinine ... #potassium #differential ... #algorithm #diagnosis ... #nephrology
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
The last step in purine ... metabolism involves ... Uricase is not present ... #UricAcid #Homeostasis ... #Gout #Pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... volume contracted: urine ... volume expanded: urine ... other • Severe potassium ... Diagnosis #Causes #nephrology