36 results
Granular & “Muddy Brown” Casts on Urine Microscopy
A. Finely granular cast B. slightly coarser granular cast
“Muddy Brown” Casts ... on Urine Microscopy ... appreciated at low ... #Urine #Microscopy ... #Clinical #Nephrology
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
Atlas of Urine Microscopy ... • Red cell casts ... • White cell casts ... key #diagnosis #nephrology ... #casts
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Uric Acid (low ... urinary excretion ... Precipitation => • Urate
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... and concentrated urine ... breakdown of cellular casts ... heme-granular casts ... #Casts #Differential
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... - Casts Acellular ... suggestive of nephrotic sydnrome ... #Urine #Microscopy ... #nephrology #interpretation
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
clots ➔ Lower Urinary ... pain hematuria syndrome ... hematuria: - RBC casts ... Upper and Lower urinary ... #urology #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Differential Diagnosis Algorithm ... Urine Cl-: Vomiting ... (late) • High Urine ... #Nephrology #Causes
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... hematuria (RBC casts ... dysmorphic RBCs in urine ... #Comparison #Algorithm ... #Nephrology #Diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Differential Diagnosis Algorithm ... Urine Cl-: Vomiting ... (late) • High Urine ... Differential #Diagnosis #Algorithm ... #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... #Proteinuria #Nephrology