8 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Uric Acid (low ... Precipitation => • Urate ... Nephropathy (low
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Algorithm for patients ... with hypokalemia ... #hypokalemia ... #differential #algorithm ... #diagnosis #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Algorithm Before ... A urine K/Cr ratio ... • Diarrhea A urine ... differential #potassium #nephrology ... #low
Causes of Hypokalemia - Differential Diagnosis Algorithm
Decreased intake (rare cause in isolation)
GI loss - Urine loss
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... isolation) GI loss - Urine ... #Nephrology #Differential ... #Diagnosis #Algorithm
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... microscopy / urinary ... electrolytes, urea ... • Cardio-renal syndrome ... Differential #Diagnosis #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Urine Na+K / serum ... Present (Uosm ≥100): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... table #sodium #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Inherited (AR) hypokalemic ... alkalosis • Normal or low ... Hypocalciuria (spot urine ... #diagnosis #nephrology ... #management #pathophysiology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... , TTKG, distal flow ... Osmoles, Increased Urate ... Tumor Lysis Syndrome ... IntercellularShift #Nephrology