461 results
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... • Mechanical hemolysis ... macroangiopathic hemolytic ... anemia" • HELLP
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... anemia): ... uremic syndrome ... diagnosis #hematology #anemia
Algorithm for the outpatient management of thrombocytopenia. 
(DIC = disseminated intravascular coagulation; EDTA = ethylenediaminetetraacetic acid;
acid; HELLP = hemolysis ... platelet count; HUS = hemolytic ... uremic syndrome
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
thrombocytopenic purpura/hemolytic ... uremic syndrome
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... uremic syndrome
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Hypertriglyceridemia • Uremia ... blood loss • Hemolytic ... anemia • Splenomegaly
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Echinocyte): Artifact, Uremia ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
to be seen in hemolytic ... microangiopathic hemolytic ... anemia in which ... intravascular coagulation, hemolytic ... - uremic syndromes
Shigellosis 
Clinical 
• High fever 
• Abdominal cramps 
• Bloody, mucoid diarrhea 
Complications 
• Bacteremia and
arthritis • Hemolytic-uremic
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Atypical HUS - Hemolytic ... Uremic Syndrome ... still present with anemia ... Atypical #HUS #aHUS #Hemolytic ... #Uremic #Syndrome