61 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Syndrome (TLS) ... Tumor Cell Lysis ... #TLS #Pathophysiology ... #UricAcid
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... Massive tumor cell lysis ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... wandering_er #Tumor #Lysis ... #Syndrome #TLS ... oncology #management #UricAcid
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Abnormalities of TLS ... Laboratory TLS ... #TumorLysis #Syndrome
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor Lysis ... Syndrome Leukostasis ... high WBC count cause ... leukapheresis - TLS ... #Syndrome #TLS
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Treatment of Clinical TLS ... MatthewHoMD #TLS ... #Tumor #Lysis # ... Syndrome #diagnosis
Causes of Hyperuricemia
Increased production
 • Solid-organ transplant
 • Tumor lysis syndrome
 • Rhabdomyolysis
 • Lesch Nyhan
Causes of Hyperuricemia ... transplant • Tumor lysis ... syndrome • Rhabdomyolysis ... • Lesch Nyhan syndrome ... #UricAcid #diagnosis
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... #Presentation #TLS
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... Deep coma (any cause ... Guillain-Barré syndrome ... injury, Early ALS ... Hyperthyroidism, Serotonin syndrome
Causes of Unprovoked Pediatric Seizures -  Epilepsy Syndromes - Differential Diagnosis Algorithm 
Infantile:
 • Benign
Causes of Unprovoked ... Seizures - Epilepsy Syndromes ... • Dravet Syndrome ... Diagnosis #Algorithm #Causes ... #Peds #Pediatrics