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Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria
2) Leukocytoclastic vasculitis
3)

Hypocomplementemic Urticarial ... HUV 1) Chronic urticaria ... Hypocomplementemic #Urticarial

Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes

Cold Urticaria Prevalence ... life Causes and clinical ... Chronic spontaneous urticaria ... Chronic inducible urticarias ... .14674 #Cold #Urticaria

Severe Urticarial Skin Rash on Physical Exam

#Urticarial #Skin #Rash #PhysicalExam #clinical #video #dermatology #urticaria

Severe Urticarial ... Physical Exam #Urticarial ... #PhysicalExam #clinical ... #dermatology #urticaria

Urticaria Mimics

Conditions That May Be Confused with Urticaria

Arthropod bites
, Atopic dermatitis
, Bullous pemphigoid
,

Urticaria Mimics ... Confused with Urticaria ... Pityriasis rosea , Urticaria ... #Differential #Urticaria

Urticaria (hives): Skin reaction that occurs in response to cold, food allergies, meds, environmental exposures, stings,
infections

Urticaria (hives ... UCSD Catalog of Clinical ... Images #Clinical ... Dermatology #SkinRash #Urticaria

Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA

bullae, Ulceration, Urticaria ... - Anti-C1q (Urticarial

Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)

Hypocomplementemic Urticarial ... Hypocomplementemic #Urticarial

Stepwise Treatment of Chronic Urticaria
Step 1 - Start second-generation HI antihistamine

Step 2 - One or

Treatment of Chronic Urticaria ... Management #Chronic #Urticaria

Causes of Urticaria

Immunoglobulin E (IgE) mediated

- Aeroallergens

- Contact allergen

- Food allergens

- Insect

Causes of Urticaria ... #Differential #Urticaria

Clarke's Test (Patellar Grind Test)

Indicates Patellofemoral dysfunction.
- Patient with knee in extension. Push posterior on

of patella then ask ... Patellar #Grind #clinical ... Patellofemoral #msk

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