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Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Hypocomplementemic Urticarial ... Vasculitis (HUV ... HUV 1) Chronic urticaria ... Leukocytoclastic vasculitis ... #Vasculitis #HUV
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Vasculitis Involving ... 50% Cutaneous Vasculitis ... Leukocytoclastic Vasculitis ... bullae, Ulceration, Urticaria ... - Anti-C1q (Urticarial
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Hypocomplementemic Urticarial ... Vasculitis C1q ... Formation -> Vasculitis ... Hypocomplementemic #Urticarial ... #Vasculitis #HUV
Causes of Urticaria

Immunoglobulin E (IgE) mediated

 - Aeroallergens

 - Contact allergen

 - Food allergens

 - Insect
Causes of Urticaria ... Lymphoma - Vasculitis ... #Differential #Urticaria ... Mediated #NonIgE #Causes
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... tract, and often causes ... Hypocomplementemic Urticarial ... - Urticaria and ... cryoglobulinemia, urticarial
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Cold Urticaria Prevalence ... decades of life Causes ... fever, fatigue, Nausea ... Chronic inducible urticarias ... .14674 #Cold #Urticaria
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of Vasculitis ... Vasculitis of ... ANCA-associated vasculitis ... hypocomplementary urticarial ... vasculitis
Pathogenesis of ANCA-associated vasculitis

Dr. Muner Mohamed @MunerMohamed1 

#ANCA #vasculitis #pathophysiology #nephrology
ANCA-associated vasculitis ... MunerMohamed1 #ANCA #vasculitis ... pathophysiology #nephrology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... tract, and often causes ... Hypocomplementemia: Urticarial ... Hypocomplementemic Urticarial ... maculopapular lesions, urticaria
Causes of Peripheral Weakness with Sensory Changes - Differential Diagnosis Algorithm
Radiculopathy:
 • Disc
 • Spondylosis
 •
Causes of Peripheral ... Multiplex: • Vasculitis ... Weakness #Sensory #Neurology ... Diagnosis #Algorithm #Causes