137 results
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Hypocomplementemic Urticarial ... Vasculitis (HUV ... HUV 1) Chronic urticaria ... Leukocytoclastic vasculitis ... #Vasculitis #HUV
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Vasculitis Involving ... 50% Cutaneous Vasculitis ... bullae, Ulceration, Urticaria ... - Anti-C1q (Urticarial ... IgM deposits • Nodular
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Hypocomplementemic Urticarial ... - Urticaria and ... pulmonary disease, and ocular ... ulcers, cutaneous, ocular ... Syndrome: - Ocular
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Hypocomplementemic Urticarial ... Vasculitis C1q ... Formation -> Vasculitis ... Hypocomplementemic #Urticarial ... #Vasculitis #HUV
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Hypocomplementemia: Urticarial ... Hypocomplementemic Urticarial ... pulmonary disease, and ocular ... ulcers, cutaneous, ocular ... Cogan syndrome: Ocular
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of Vasculitis ... Vasculitis of ... ANCA-associated vasculitis ... hypocomplementary urticarial ... vasculitis
Pathogenesis of ANCA-associated vasculitis

Dr. Muner Mohamed @MunerMohamed1 

#ANCA #vasculitis #pathophysiology #nephrology
ANCA-associated vasculitis ... MunerMohamed1 #ANCA #vasculitis ... pathophysiology #nephrology
Causes of Urticaria

Immunoglobulin E (IgE) mediated

 - Aeroallergens

 - Contact allergen

 - Food allergens

 - Insect
Causes of Urticaria ... Lymphoma - Vasculitis ... #Differential #Urticaria
Behcet's Syndrome - Diagnosis
Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease):
 • Recurrent,
genital ulcers - Ocular ... Uveitis or retinal vasculitis ... erythema nodosum) • Ocular ... uveitis, retinal vasculitis ... neurological and ocular
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... gangrenosum) • Urticaria ... Granulomatous vasculitis ... • Necrotising vasculitis ... leukocytoclastic vasculitis