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diagnosis algorithm causes pulmonary management renal acute aki antigbm basement classification comparison disease giomeruiar glomerular goodpastures hematuria kidneyinjury membrane myelitis
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... polyangiitis, Microscopic ... ab, anti-GBM ab ... biopsy By Tess Litchman ... #diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... antibodies ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
of Hematuria - Differential ... cells on urine microscopy ... disease • ... wall) • Anti-GBM ... antibodies
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Injury (AKI) - Differential ... Glomerulonephritis • Anti-GBM ... antibodies • ... polyangiitis /microscopic ... #KidneyInjury #Nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... EGPA) • Auto-antibodies ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Urticarial Vasculitis (anti-C1q ... Dx: GPA, EGPA, microscopic ... C-ANCA) pattern: antibodies
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
levels • NMO-IgG (anti-AQP4 ... Brucellosis - Dengue, EBV ... AntiCRMP IgG, Anti-Hu ... Antiamphiphysin antibodies ... #differential
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