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diagnosis differential rheumatology algorithm pulmonary renal vasculitis acute aki ana antibodies antibody antineutrophil antinuclear classification comparison glomerular glomerulonephritis injury kidney
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
of cases) 2 ... connective tissue disease ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... disease - MPO>PR3
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... differential #diagnosis #nephrology
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
: • C-ANCA: GPA ... : Microscopic Polyangiitis ... Churg Strauss) Anti-GBM ... differential #diagnosis #nephrology ... #causes
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits: ANCA ... , ANA, Anti-GBM, ... Differential #Diagnosis #nephrology ... #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... Urticarial Vasculitis (anti-C1q ... Dx: GPA, EGPA, microscopic
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... life-threatening diseases ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
)): Microscopic ... tract, and often causes ... abdominal pain and GN Anti-GBM ... Urticarial Vasculitis (anti-C1q ... Urticarial Vasculitis (anti-C1q
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