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diagnosis differential algorithm pulmonary causes management neurology renal acute aki antigbm basement comparison cord disorders giomeruiar glomerular goodpastures hematuria kidney
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #glomerular #diseases
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific ... ab, anti-GBM ab
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Acute Kidney Injury ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... Differential #Diagnosis #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease ... with polyangiitis/microscopic
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... quantify renal injury ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Basement Membrane Disease ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... Basement #Membrane #Disease ... AntiGBM #diagnosis #nephrology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
below the site of injury ... below the site of injury ... Mycoplasma, Influenza, EBV ... Hemorrhage - Ant ... Sarcoidosis, Behcet disease
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
super-antigen mediated disease ... Presentation: Injury ... Pallidum - Lyme Disease ... MCTD - Bechet disease ... AntiCRMP IgG, Anti-Hu
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