9 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Renal Syndromes ... sclerosis • Anti-Glomerular ... ab, anti-GBM ab ... #Renal #Syndrome
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Nephrotic syndrome ... Amyloid RPGN • Anti-GBM ... #diseases #nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Diagnosis: • Anti-GBM ... #Membrane #Disease ... AntiGBM #diagnosis #nephrology ... #pulmonary
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Thin basement membrane ... disease - Alport ... pain hematuria syndrome ... disease Renal ... causes #urology #nephrology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... membrane: Goodpasture ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... #Renal #Syndromes
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
(Dense deposit disease ... microangiopathy (TMA), anti-phospholipid ... syndrome, post-bone ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
and renal abnormalities ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
and renal abnormalities ... • Kidneys: Non-glomerular ... (PR3-ANCA)): Microscopic ... abdominal pain and GN Anti-GBM ... vasculitis • Cogan syndrome