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diagnosis differential rheumatology vasculitis anca acute aki ana antibodies antibody antigbm antineutrophil antinuclear associated basement canca classification comparison disease giomeruiar
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... polyangiitis, Microscopic ... ab, anti-GBM ab ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... • Lupus ISN/RPS ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... diseases with pulmonary ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... #Pulmonary #Renal
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Vasculitis: • Microscopic ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... ANCA+ 90% • Anti-GBM ... disease - MPO>PR3
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Diagnosis Framework PRE-Renal ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... Differential #Diagnosis #nephrology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... polyangiitis without renal ... >MPO Microscopic ... Renal-limited ... Anti-GBM disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
and renal abnormalities ... -ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
and renal abnormalities ... -ANCA)): Microscopic ... abdominal pain and GN Anti-GBM ... Urticarial Vasculitis (anti-C1q ... Urticarial Vasculitis (anti-C1q
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology ... #pulmonary
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