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diagnosis differential rheumatology vasculitis acute aki anca injury kidney ana antibodies antibody antigbm antineutrophil antinuclear associated canca causes classification comparison
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... ab, anti-GBM ab
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #glomerular #diseases
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... diseases with pulmonary ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
classified into pre-renal ... and interstitial disease ... GBM, Glomerular ... basement membrane ... Causes #Sites #Nephrology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Vasculitis: • Microscopic ... ANCA+ 90% • Anti-GBM ... disease - MPO>PR3 ... #rheumatology #diseases
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Diagnosis Framework PRE-Renal ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... Differential #Diagnosis #nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Disease (Goodpasture's ... Disease) What ... Diagnosis: • Anti-GBM ... #Membrane #Disease ... #pulmonary
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... polyangiitis without renal ... >MPO Microscopic ... Renal-limited ... Anti-GBM disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
glomerulonephritis) • Anti-GBM ... disease, and ocular ... (Granulomatous disease ... atherosclerotic disease ... most important diseases
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Systemic rheumatic diseases ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE ... abdominal pain and GN Anti-GBM
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