27 results
diagnosis differential management algorithm vasculitis antibodies hematology neurology renal treatment anca antinuclear autoantibodies classification disorders glomerulonephritis hemophagocytic hlh lymphohistiocytosis summary
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #glomerular #diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... - Graves' disease ... (TTG) - Celiac disease ... Anti-GBM - Goodpasture's
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... disease - MPO>PR3 ... #diseases
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Diffuse skin disease ... : Limited skin disease ... Biliary Cirrhosis Anti-RNA ... , Overlap BCM IM ... Autoantibodies #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... involvement: Anti-GBM ... Disease (Goodpasture's
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
) ANA or Anti-NucIear ... Using fluorescence microscopy ... Disease! ... , Interstitial Pulmonary ... #patterns #rheumatology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease ... with polyangiitis/microscopic
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause
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