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diagnosis differential vasculitis management pulmonary acute aki algorithm antibodies antibody antineutrophil antinuclear associated canca classification injury kidney mpo panca polychondritis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Vasculitis: • Microscopic ... polyangiitis without renal ... + 90% • Anti-GBM ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3 ... @AnnKumfer #ANCA ... #Diagnosis #Rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits: ANCA ... , ANA, Anti-GBM, ... Anti-ds-DNA, C3 ... Differential #Diagnosis #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
renal abnormalities ... often causes arthritis ... glomerulonephritis) • Anti-GBM ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... Auto-antibodies: ANCA ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
renal abnormalities ... )): Microscopic ... often causes arthritis ... GN Anti-GBM (10 ... Differential #Diagnosis #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Heart failure • Renal ... specific): ○ Anti-Matrilin ... Nonspecific ↑ ESR, CRP, ANA ... affected tissue Treatment ... Polychondritis #rheumatology
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