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diagnosis differential diseases glomerulonephritis anca antibodies antibody antinuclear classification comparison glomerular membranoproliferative pathology pulmonary rheumatology rpgn syndrome table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... (Antineutrophil ... Anti-Sm (Smith) ... Vasculitis: • Microscopic ... + 90% • Anti-GBM
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... GN • Amyloid RPGN ... • Anti-GBM disease ... #nephrology #pathology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
(Dense deposit disease ... immune deposits on EM ... microangiopathy (TMA), anti-phospholipid ... #nephrology #diagnosis ... #renal
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Basement Membrane ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... of glomerular disease ... Basement Membrane ... staining on IF • No EM ... Differential #Diagnosis #Nephrology
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