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diagnosis differential pulmonary causes classification nephrotic proteinuria renal rheumatology syndrome vasculitis acute aki antigbm basement giomeruiar glomerulonephritis goodpastures hematuria injury
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
diseases Light ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #diseases #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
disease (hematuria ... post-infectious GN Anti-Glomerular ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... Differential #Diagnosis #Nephrology
Spectrum of Glomerular Diseases Nephrotic - Mechanism: • Injury to podocytes • Changed architecture: Scanning. Deposition of
Diseases Nephrotic ... • Breaks in GBM ... #Diseases #differential ... spectrum #diagnosis #nephrology ... nephritic #nephrotic #comparison
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... nephropathy • Thin GBM ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... sclerosis • Anti-Glomerular ... Goodpasture's Disease ... ab, anti-GBM ab
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
• Vascular • Glomerular ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... Differential #Diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Basement Membrane Disease ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... #Membrane #Disease
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... Cytomegalovirus; GBM ... impairment), heart disease ... diagnosis cluster, the diseases ... nephrotic #syndrome #nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... hypercellular glomeruli
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