11 results
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #diseases #nephrology ... #table #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
disease (hematuria ... post-infectious GN Anti-Glomerular ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... #Nephrology
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
Spectrum of Glomerular ... • Breaks in GBM ... #spectrum #diagnosis ... #nephrology #nephritic ... #nephrotic #comparison
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... polyangiitis, Microscopic ... sclerosis • Anti-Glomerular ... ab, anti-GBM ab ... #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
- Differential Diagnosis ... cells on urine microscopy ... nephropathy • Thin GBM ... disease • ... wall) • Anti-GBM
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
- Differential Diagnosis ... • Vascular • Glomerular ... Immune-complex disease ... , Anti-GBM • Tubular ... #nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... directed against the glomerular ... : • Anti-GBM antibodies ... weeks By Tess Litchman ... #nephrology #pulmonary
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... hypercellular glomeruli
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Vasculitis - Skin, glomeruli ... : - Kidneys: glomerular ... Dx: GPA, EGPA, microscopic