14 results
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
diseases Light ... Microscopy (EM) ... Minimal change disease ... RPGN • Anti-GBM ... #diseases #nephrology
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
Diseases Nephrotic ... • Breaks in GBM ... #Diseases #differential ... spectrum #diagnosis #nephrology ... nephritic #nephrotic #comparison
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
with evidence of glomerular ... disease (hematuria ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... Differential #Diagnosis #Nephrology
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... nephropathy • Thin GBM ... disease • ... ) • Anti-GBM ... • Pauci-immune disease
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
vascular supply; glomerular ... and interstitial disease ... GBM, Glomerular ... Causes #Sites #Nephrology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific ... anti-ANCA ab, anti-GBM
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
• Vascular • Glomerular ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... Differential #Diagnosis #nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... syndrome—due to GBM ... diabetes)) #Glomerular ... #Diseases #Nephritic ... #Proteinuria #Nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Basement Membrane Disease ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... Basement #Membrane #Disease ... AntiGBM #diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology