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diagnosis differential pulmonary glomerulonephritis renal algorithm antigbm causes classification clinical disease electronmicroscopy giomeruiar glomerulus goodpastures management membrane membranous mgn proteinuria
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #diseases #nephrology ... #pathology #comparison
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
disease (hematuria ... post-infectious GN Anti-Glomerular ... Basement Membrane ... (GBM) • Typically ... Linear, ribbon-like GBM
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... directed against the glomerular ... Diagnosis: • Anti-GBM ... #GIomeruIar #Basement ... AntiGBM #diagnosis #nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... sclerosis • Anti-Glomerular ... Basement Membrane ... ab, anti-GBM ab ... differential #diagnosis #nephrology
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
Glomerulonephritis on Electron Microscopy ... second layer of basement ... completely bridged GBM ... SEM #clinical #nephrology ... #pathology
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 Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... life-threatening diseases ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... hypercellular glomeruli
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