8 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Differential Diagnosis ... (>1000): • DILI ... Drug-induced liver injury ... #Tests #LFTs #Differential ... #Diagnosis #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... ) vs Indirect (Hemolytic ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Diagnosis Algorithm ... • Iatrogenic: DILI ... extrahepatic source - Tests ... of synthetic function ... #diagnosis #algorithm
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... LFTs) - Normal Values ... hepatocellular injury ... Overproduction (hemolysis ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... Bilirubin: RBC (hemolysis ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver ... #Enzymes #Differential
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Diagnosis Algorithm ... that a one-off value ... Best to have an ... #Diagnosis #Algorithm