11 results
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
with devastating differential ... petechial or purpuric rash ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash ... #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... deficiency • Liver ... palpable #nonpalpable
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... infiltration) Differential ... #Pregnancy #hepatology ... obgyn #diagnosis #management ... #pathophysiology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Arterial Thrombosis - Differential ... Syndrome, Ischemic Liver ... Heparin-induced thrombocytopenia ... Venous #Arterial #pathophysiology ... #hematology #differential
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... protein C and S Pathophysiology ... DIC • Severe Liver ... causes #treatment #management ... #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Interpretation of LFTs R-value ... disease: > 2 • NASH ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Petechial or purpuric rash ... leukopenia, anemia, and thrombocytopenia ... • Liver function ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... purpura & severe thrombocytopenia ... eruptions, diarrhea, liver ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
maculopapular rash ... purpura & severe thrombocytopenia ... eruptions, diarrhea, liver ... Transfusions #diagnosis #management ... #hematology #reactions