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diagnosis differential algorithm workup management hemolysis hemolytic intravascular oncology cirrhosis classification elevatedmcv extravascular macrocytosis syndrome anemias aplastic approach bandemia bariatric
Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
Pathophysiology ... of Hemolytic Anemia ... - Defects in RBC ... - Defects in RBC ... #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Diagnosis Algorithm Signs ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Artifact (redo CBC ... Iron deficiency anemia ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... Diagnosis #Algorithm #Causes ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs Decreased RBC ... Thalassemia • RBC ... Disorder • RBC ... Diagnosis #Algorithm #Causes ... #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... limb ischemia, bowel ... : WBC >100k, + lab ... signs of end organ ... diagnosis #management #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Neutrophils - Low RBC ... • Small Bowel ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... changes), high MCV anemia ... disease), HBsAg/anti-HBc ... or if a primary hematologic ... #Workup #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... - Fe/TlBC, MCV/RBC ... TIBC Normal - MCV/RBC ... inclusions in RBC ... #Hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... Pathophysiology ... intralobular bile ducts causes ... Signs and Symptoms ... diagnosis #workup #hepatology
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