22 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Primary Biliary Cirrhosis ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary Cirrhosis ... Diagnosis Algorithm Symptoms ... Liver biopsy findings ... #Biliary #Cirrhosis ... Diagnosis #Algorithm #hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Folate deficiency, Liver ... , Liver disease, ... Unstable hemoglobin disorders ... stomatocytosis, Liver ... differential #diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... /Liver failure ... Symptoms: • 50 ... or higher • Liver ... diagnosis #workup #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
: INR/PT, aPTT(liver ... pylori test (GI symptoms ... changes), high MCV anemia ... bypass), LFT (liver ... Causes #Workup #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Neutrophils - Low RBC ... • Small Bowel Disorder ... WBCs - Normal Liver ... Tests • Liver ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... 2) External (RBC ... Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Differential #Diagnosis #hematology
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... experience some symptoms ... Pancytopenia is a hematologic ... involves production disorders ... that involves disorders
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... priapism • Lab values ... Lysis Syndrome: • Pathophysiology ... sudden death • Lab values ... diagnosis #management #hematology
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
CIRRHOSIS - ... indications for liver ... Care focuses on symptom ... and end-stage liver ... management #summary #Hepatology