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Initial Clinical and Laboratory Data Base for Defining Major Syndromes in Nephrology

#Major #Syndromes #Nephrology #Diagnosis #Workup
Defining Major Syndromes ... in Nephrology ... #Major #Syndromes ... #Workup #Differential ... #Table
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Between Nephrotic Syndrome ... and Nephritic Syndrome ... == Nephrotic Syndrome ... == Nephritic Syndrome ... #Nephrotic #Syndrome
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Aldosterone: Liddle's Syndrome ... SAME, Cushing Syndrome ... diuretics, Bartter syndrome ... , Gitelman syndrom ... Diagnosis #Algorithm #causes
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
renal Mg wasting syndromes ... - Gitelman syndrome ... - Hungry bones syndrome ... #Magnesium #Table ... #Workup #hypomg
Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Workup of Hypercalcemia ... Hypercalcemia Low ... disease, Milk Alkali Syndrome ... disease, Viral Syndromes ... #nephrology #PTH
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Diuretics, Bartter Syndrome ... , Gitelman Syndrome ... GRA, Cushing's syndrome ... , Liddle syndrome ... #Causes
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... differential #diagnosis #table ... #neurology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... alkalosis, Hungry bone syndrome ... Tumor genesis syndrome ... FGF-23: Fanconi syndrome ... #phosphate #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
acid, Liddle's Syndrome ... R - Cushing's syndrome ... Diuretics, Bartter's syndrome ... , Gitelman's syndrome ... #causes #low #potassium
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
of hypokalemia starts ... Diuretics, Bartter's syndrome ... , Gitelman's syndrome ... acid, Liddle's syndrome ... • Cushing's syndrome