18 results
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
→ liver test abnormalities ... Other: NAFLD, Autoimmune ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Severe Acute Liver Injury ... - Autoimmune ... disease - Hemochromatosis ... #Differential #Hepatology ... #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Liver Function Tests ... (LFTs) - Differential ... Diagnosis Framework ... Drug-induced liver injury ... #Diagnosis #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential Diagnosis ... Other: NAFLD, Autoimmune ... #Differential #Diagnosis ... Acute #algorithm #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
of Autoimmune Hepatitis ... >1.5, and both values ... atypical laboratory tests ... #Hepatitis #Diagnosis ... #Hepatology #AIH
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Ischemia • Autoimmune ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... symptoms of liver disease ... Calculate R-Value ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... • Autoimmune: ... Autoimmune hepatitis ... extrahepatic source - Tests ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... R-value: Serum ... liver #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs