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hematology anemia differential hemolysis hemolytic adrenal cold insufficiency primary table addisons aiha antiglobulin causes comparison dat direct extravascular hepatitis hepatology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis ... hemoglobinuria) • Cold Agglutinin ... Disease Mixed-type ... #Table #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... CLL (older) • Autoimmune ... test #cold # ... agglutinin #disease
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
( +/- ) Cold agglutinin ... disease • DAT ... #antiglobulin #test ... #Hemolysis #hematology ... #diagnosis
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Autoimmune diseases ... contact with cold air ... fatigue, Nausea, abdominal ... Cold #Urticaria #diagnosis ... #rheumatology #
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Laboratory Tests ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... (AIHA) "Warm" ( ... (AIHA)"Cold" (usually ... . primary cold agglutin ... #hematology #anemia
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
Cause in the US: Autoimmune ... or metastatic disease ... ) w/ anorexia, abdominal ... A STIM test can ... #Management #Endocrinology
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Nausea/vomiting • Abdominal ... Serum DHEAS Diagnosis ... /dL -> Primary AI ... #endocrinology ... #diagnosis #signs
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... atypical laboratory tests ... #Hepatology #AIH
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