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diagnosis rheumatology differential lupus erythematosus management vasculitis causes champs comparison criteria cryoglobulinemia cryoglobulins dermatology disorders druginduced eularacr hypocomplementemia low lymphomas
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... pericarditis • Hematologic ... anticoagulant • Complement ... #Criteria #SLE
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... - CHAMPS Mnemonic ... glomerulonephritis (>90%) S - Systemic ... Hypocomplementemia #Low #Complement ... #differential #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... 90% - Low complement ... months to years) Systemic ... 80% - Low complement ... comparison #table #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... RNP antibodies, Complement
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Abnormality • SLE ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm ... #causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... erythematosus (SLE ... diagnosis #types #classification ... #rheumatology #
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
site in lymphatic system ... with lymphatic system ... are present • Classic ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... against MPO • Complement ... vasculitis, and SLE ... differential #diagnosis #rheumatology ... #classification
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... frequently affected systems ... Better call hematology ... some time, let’s see ... #workup #hematology
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