7 results
Stroke and bleeding risk stratification with the CHADS2-VASc and HAS-BLED schemas

#Diagnosis #Hematology #CHADS2 #CHADS2VASc #HASBLED #Comparison
Stroke and bleeding ... #Diagnosis #Hematology ... CHADS2 #CHADS2VASc #HASBLED ... Stroke #Bleed #Anticoagulation
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
clinical benefit of anticoagulation ... of withholding anticoagulation ... risk #HASBLED ... #Calculators #Anticoagulation ... #Factors #Hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... lead to severe bleeding ... management #algorithm #pharmacology ... #medications #table ... decisionaid #cardiology #hematology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
bleed risk on anticoagulation ... S Stroke 1 B Bleeding ... CHADS2 #CHADS2VASc #HASBLED ... Stroke #Bleed #Anticoagulation ... AFib #Diagnosis #Hematology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
patients on chronic anticoagulation ... per treatment table ... and procedural bleeding ... with a very low bleeding ... Management #Treatment #pharmacology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
DOACs thereby leading ... metabolization leading ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Bleeding Risk for Various Invasive/Surgical Procedures
Low Risk:
 • Dental extractions (1 or 2 teeth), endodontic (root
Bleeding Risk for ... Cataract surgery • Dermatologic ... placement (if bridging anticoagulation ... polypectomy) #Bleeding ... Perioperative #Procedures #Table