9 results
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
thereby leading ... metabolization leading ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... per treatment table ... and procedural bleeding ... with a very low bleeding ... Management #Treatment #pharmacology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
lead to severe bleeding ... management #algorithm #pharmacology ... #medications #table ... decisionaid #cardiology #hematology
Shock and Vasoactive Drugs 
1) Determine type and etiology of shock
 • Distributive: Sepsis, Anaphylaxis, Neurogenic
• Hypovolemic: Bleeding ... vasoactive drug pharmacology ... Vasoactive #Drugs #pharmacology ... #inopressors #diagnosis ... management #comparison #table
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
LMWH, warfarin, DOACs ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome • Diagnosis ... roentgenography • Bleeding ... with specific bleeding ... Diuresis #Nephrology #Pharmacology ... #Medications #Table
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
Differential Diagnosis ... Avoid Warfarin and DOAC ... during Delivery • Stable ... Period • Breast-feeding ... Cardiomyopathy #diagnosis
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
simply a clinical diagnosis ... establishing a diagnosis ... causing hypovolemia needing ... cardiology #treatment #table ... icu #clinical #pharmacology
Monkeypox

What?
Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus
Viral zoonotic disease that is
rectal pain, rectal bleeding ... involved DDX: Varicella ... Monkeypox #MPOX #Diagnosis ... #Management #Dermatology