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diagnosis management differential disease leukemia mds myelodysplastic neurology syndromes workup activation anemia antiphospholipid aplastic apls bee behcet cancer capillary cerebritis
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
• Clinically ... suspect underlying hematologic ... Diagnosis and Treatment ... Algorithm Matthew ... #HES #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... only curative treatment ... Myelodysplastic #Syndrome ... #hematology #oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... #neurology #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes ... nervous system (CNS ... diagnosis and treatment ... Non-inflammatory causes ... MRI lesions and clinical
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... basal ganglia, CNS ... (Clinical Dx). ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Infections+++: Virus ... Drugs, Unknown cause ... Treatment: • ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... nervous system (CNS ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... Thromboembolism (7%) • CNS ... Treat primary cause ... #treatment #management ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Out Secondary Causes ... #diagnosis #hematology ... #oncology
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