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diagnosis management lupus druginduced erythematosus oncology summary systemic anemia antiphospholipid aplastic apls chronic cll cns comparison dil hemophagocytic hlh hypercoagulable
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Demyelinating Syndrome ... autoantibodies that will cause ... CNS #neurology #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Immunologic Workup ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... comparison #table #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Infections+++: Virus ... Autoimmune diseases: SLE ... Treatment: • ... #summary #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... • Epstein-Barr virus ... aplastic anemia Treatment ... Anemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... Adenocarcinoma Treatment ... #Rheumatology #
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome ... Hypercoagulable Workup ... - 1 or more clinical ... maternal chromosomal causes ... #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... DrugInduced #Lupus #DIL #rheumatology ... #diagnosis #treatment
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
the most common clinical ... such as: • SLE ... Diagnosis: • Clinical ... affected tissue Treatment ... Polychondritis #rheumatology
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