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diagnosis differential causes chronic cll lad lymphocytic management aplastic classification disorders focal hemeonc leukemoid leukocytosis localized lymphomas lymphoproliferative nonhodgkin pathophysiology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... and Localized Lymphadenopathy ... • Neoplastic (Leukemia ... #Causes #Hematology ... #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lymphadenopathy ... #Lymphadenopathy ... #Causes #Hematology ... #Oncology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... immunosuppression • Exam: lymphadenopathy ... hepatomegaly • Labs: anemia ... #hematology #WBC ... #Leukemoid
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
pain • Bulky lymphadenopathy ... & BM • Bulky lymphadenopathy ... infections, and lymphadenopathy ... - infiltrates (anemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
) Asymptomatic lymphadenopathy ... 5) Symptoms of anemia ... Symptomatic massive lymphadenopathy ... marrow failure with anemia ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
early symptoms • Lymphadenopathy ... Exam/Signs: • Lymphadenopathy ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... immunodeficiency virus ... • Epstein-Barr virus ... (EBV) • Leukemia ... #oncology #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... (NHL) ~60% - lymphadenopathy ... more diffuse, can ... Treated Like Acute Leukemias ... pathophysiology #Hematology
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