12 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... #Localization #Nephron ... #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... in the distal tubule ... delivery to distal nephron ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... vasopressin control #Nephron ... Segments #Function #Pathophysiology ... #Pharmacology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential ... hypokalemia • Renal tubular ... Bartter's syndrome, Gitelman's ... #hypokalemia #differential ... #nephrology #potassium
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
Causes of Metabolic ... Alkalosis - Differential ... Losses - Impaired tubular ... Hypomagnesemia • Barrter's/Gitelman's ... MetabolicAlkalosis #NonGap #Nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... cotransporter in distal tubule ... loss through the nephron ... #nephrology #conversion ... loop #thiazide #classes
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Common causes of ... , Lupus Acute Tubular ... Abhilash Koratala @NephroP ... #AKI #causes ... #Diagnosis #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... ratio 0.5%) Differential ... syndrome, Renal tubular ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Bartter syndrome, Gitelman ... high in kidney tubular ... the indicated causes ... urine #Algorithm #nephrology ... #differential #
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... Alkalosis: Differential ... furosemide-like lesion) • Gitelman ... #Diagnosis #Causes ... #nephrology