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diagnosis management hematology neurology causes oncology algorithm symptoms anemia disease vasculitis barre classification fever guillain hemolysis hemophagocytic hlh lymphohistiocytosis night
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm Signs ... Hypersplenism, Infection ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... uremic syndrome ... spherocytosis) • Infections ... Extravascular #Causes #differential ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... deficiency Infections ... • Epstein-Barr virus ... #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Thrombocytosis #Platelets #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Internal (RBC) - Infections ... #Differential # ... Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... - Due to Viral infection ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
Causes of Sore Throat / Rhinorrhea - Differential Diagnosis Algorithm Common viral pathogens: Rhinovirus, Coronavirus, Influenza virus,
/ Rhinorrhea - Differential ... : Group A Beta Hemolytic ... Acute Head Cold Syndrome ... Tracheobronchitis • Acute Infectious ... SoreThroat #Rhinorrhea #Differential
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
diagnosis and treatment ... • Enteroviral infections ... • Herpes virus ... infections • ... noninflammatory #differential
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... +++: Virus (EBV, ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
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