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differential management hematology neurology vasculitis apml arthritis autoimmune behcet causes central chronic classification cll cord dermatology differentiation disease disorders heartfailure
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... , dyspnea, +/- CXR ... WBC >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Cathepsin G release → vascular ... common • Imaging: CXR ... : >3 symptoms, or ... #oncology
Heart failure with Reduced Ejection Fraction (HFrEF) Clinical Presentation 1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
More Specific Signs ... Less Specific Signs ... Chest x-ray: signs ... acute HF → no signs ... of CXR congestion
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
trunk, face or neck ... Episcleritis Signs ... and Symptoms: ... legs, face or neck ... #oncology
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Rheumatoid Arthritis - Signs ... Thrombocytosis, Felty's syndrome ... Arthritis #RA #Signs ... #Symptoms #diagnosis ... #rheumatology
Causes of Peripheral and Central Vertigo PERIPHERAL VERTIGO 1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
Vascular disorders ... Can occur with neck ... Syndrome usually ... varying neurologic signs ... #differential #diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
meningitis), MCC CNS symptoms ... and diplopia) • Vascular ... ) Differential Diagnosis ... #signs #symptoms ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential Diagnosis ... and signs below ... Vascular/Blockage ... MCTD, Sjogren syndrome ... differential #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... pulse deficits vascular ... • Progressive symptoms ... #Rheumatology
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