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hematology oncology management chronic hemeonc leukemia differential differentiation emergencies hemophagocytic hlh lymphocytic lymphohistiocytosis oncologic pericarditis sarcoidosis signs vasculitis workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... ALL Symptoms: ... manifestations, hypoxia, CXR ... ) CLL Symptoms: ... #Oncology #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Cathepsin G release → vascular ... : >3 symptoms, or ... #APML #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Diagnosis: • ... • Richter’s Syndrome ... Transform to DLBCL, PML
Pericarditis - Definition and Diagnostic Criteria Acute Pericarditis • Inflammatory pericardial syndrome to be diagnosed with
Inflammatory pericardial syndrome ... and white blood cell ... CMR). ... pericarditis and a symptom-free ... #criteria #cardiology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... at the time of diagnosis ... e.g. incidental CXR ... anterior/posterior MSK ... #Management #Signs
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
interventional radiology ... ± tocilizumab; call ... : - Seen with AML ... (~20 %) and APL ... Oncology #HemeOnc #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... pulse deficits vascular ... • Progressive symptoms ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Presentation • Common Signs ... and Symptoms: ... Diagnostic Criteria ... of 8 HLH-2004 criteria ... #Management #Hematology
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