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diagnosis differential joint msk pain symptoms vasculitis arthritis classification erythematosus management systemic approach bone centralretinalartery cerebritis cns crao cryoglobulinemia cryoglobulins
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
(SLE): Musculoskeletal ... Myopathy (Also caused ... Musculoskeletal #Complications ... #pathophysiology ... #signs #symptoms
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... other orthopedic complications ... Avascular necrosis ... dz difficult to see ... #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Vascular Sludging ... (e.g. systemic lupus ... classification #rheumatology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
GCA, SLE, GPA) - ... anti-coagulation • Hematologic ... retinal edema caused ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis #signs
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... weeks) Can Be Caused ... arthritis • SLE ... Symmetrical: • RA • SLE ... Diagnosis #MSK #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
spondyloarthropathies, lupus ... Non-bloody: OA, avascular ... Like in this case ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... purpura: strong sign ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... pulse deficits vascular ... tract, and often causes ... Differential #Diagnosis #Rheumatology
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